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. Author manuscript; available in PMC: 2011 May 4.
Published in final edited form as: J Neurochem. 2009 Mar 19;109(4):1144–1156. doi: 10.1111/j.1471-4159.2009.06042.x

Figure 4. TREM2 is sufficient to confer phagocytosis of apoptotic Neuro2A.

Figure 4

CHO cells stably transfected to express TREM2/DAP12 or TREM1/DAP12 chimeras were assessed for their phagocytosis of apoptotic Neuro2A cells. Flow cytometry confirmed that the transfected CHO cells express either TREM2 (filled histogram, left) or TREM1 (filled histogram, middle) on cells gated for GFP, while isotype controls (open histograms) did not bind to the CHO cells. The expression of TREM2/DAP12 (black bar) was sufficient to increase phagocytosis of apoptotic Neuro2A cells by 1.7 fold over untransfected cells CHO cells (white bar), while expression of TREM1/DAP12 did not (gray bar) (n=8, * p-value < 0.05).