Table 1. Homologous recombination proteins in E. coli, S. cerevisiae and humans.
| E. coli | S. cerevisiae | Human | |
|---|---|---|---|
| Initiation | RecBCD | - | - |
| SbcCD | Mre11-Rad50-Xrs2 | Mre11-Rad50-Nbs1 | |
| RecQ | Sgs1 | RecQL, RecQ4, RecQ5, BLM, WRN | |
| RecJ | ExoI | ExoI | |
| UvrD | Srs2 | Fbh1? | |
| Homologous pairing and DNA strand exchange | RecA | Rad51, Dmc1 | Rad51, Dmc1 |
| SSB | RPA | RPA | |
| RecF(R) | Rad55-Rad57 | Xrcc3-Rad51C | |
| Shu1-Psy3-Shu2-Csm2 | Xrcc2-Rad51D-Sws1 | ||
| Rad51B | |||
| RecO(R) | Rad52 | Rad52 | |
| - | Rad59 | - | |
| - | - | Brca2-Dss1 | |
| - | Rad54, Rdh54/Tid1 | Rad54 | |
| Rad54B | |||
| DNA Heteroduplex Extension | RuvAB | Rad54 | Rad54 |
| RecG | - | - | |
| RecQ | Sgs1 | RecQL, RecQ4, RecQ5, BLM, WRN | |
| Resolution/Dissolution | RuvC | - | Resolvase A |
| RecQ-TopoIII | Sgs1-TopIII-Rmi1 | BLM-TopoIII α-BLAP75 | |
| - | Mus81-Mms4 | Mus81-Mms4/Eme1 |