Figure 2.

Structural comparisons between mPERK KD and PKR KD. (a) Superimposition of the mPERK KD N-lobe (gold) with the active PKR KD N-lobe (silver). The N-termini of mPERK KD and PKR KD are labeled. Helix αC2 in mPERK KD is also labeled. The disordered regions are represented by dashed lines. (b) Superimposition of mPERK KD C-lobe with active PKR KD C-lobe (left) and inactive PKR KD C-lobe (right). mPERK molecules are colored gold and PKR molecules are colored silver. Phosphorylated Thr residues are shown as ball-and-stick models. The missing parts of the mPERK activation loop are indicated by dashed lines.