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. 2011 Apr 21;67(Pt 5):556–560. doi: 10.1107/S174430911100724X

Figure 1.

Figure 1

The domain arrangement of R6IP1, with the deletion between α3 and α4 indicated. The acronym DENN refers to differentially expressed in neoplastic versus normal cells, while uDENN refers to the ‘upstream’ DENN domain and dDENN refers to the ‘downstream’ DENN domain. Also shown is a sequence alignment of the RUN1 and RUN2 domains of R6IP1, the RUN domains of human Rap2IPx (RPIPX; NP_001032519.1 residues 65–236), murine RabIP4 (NP_766145.1 residues 113–286) and the engineered RUN1 domain of RPdel. The asterisks in the R6IP1del sequence represent residues which have been deleted from the loop spanning α-helices 3 and 4 of murine R6IP1. The residue numbering above is in accordance with that adopted in the structure deposited as PDB entry 3cwz; however, it is worth noting that residue 719 of Rab6IP1 above corresponds to residue 743 of the full-length Denn5a gene sequence (Gene ID 19347).