Table 2.
HRs for eGFR on cause-specific mortality
| Causes of Death | eGFR (ml/min per 1.73 m2) |
P, trend | CKD Status |
|||||
|---|---|---|---|---|---|---|---|---|
| ≥60 | 45 to 59 | 30 to 44 | 15 to 29 | <15 | Non-CKD | CKD | ||
| All-cause mortalitya (n = 2,710) | 1 (Ref) | 1.35 (1.20 to 1.51)c | 2.30 (1.89 to 2.78)c | 3.50 (2.58 to 4.76)c | 6.39 (4.30 to 9.49)c | <0.001 | 1 (Ref) | 1.62 (1.46 to 1.79)c |
| CV mortalitya (n = 523) | 1 (Ref) | 1.62 (1.28 to 2.06)c | 2.81 (1.93 to 4.09)c | 2.59 (1.27 to 5.26)d | 9.14 (4.31 to 19.37)c | <0.001 | 1 (Ref) | 1.92 (1.55 to 2.36)c |
| stroke mortalitya (n = 174) | 1 (Ref) | 1.37 (0.89 to 2.12) | 1.89 (0.86 to 4.12) | 2.06 (0.50 to 8.41) | 13.92 (5.11 to 37.95)c | <0.001 | 1 (Ref) | 1.64 (1.12 to 2.40)e |
| CHD mortalitya (n = 150) | 1 (Ref) | 1.78 (1.15 to 2.73)d | 3.92 (2.13 to 7.21)c | 4.20 (1.50 to 11.73)d | 15.03 (4.73 to 47.79)c | <0.001 | 1 (Ref) | 2.31 (1.59 to 3.36)c |
| Non-CV mortalityb (n = 2,187) | 1 (Ref) | 1.25 (1.10 to 1.42)d | 2.21 (1.77 to 2.75)c | 3.83 (2.75 to 5.32)c | 6.89 (4.43 to 10.72)c | <0.001 | 1 (Ref) | 1.52 (1.36 to 1.70)c |
| cancer mortalityb (n = 1,117) | 1 (Ref) | 1.10 (0.91 to 1.32) | 1.54 (1.08 to 2.20)e | 2.12 (1.17 to 3.86)e | 1.93 (0.62 to 5.98) | 0.004 | 1 (Ref) | 1.20 (1.02 to 1.42)e |
| infection mortalityb (n = 99) | 1 (Ref) | 1.11 (0.66 to 1.86) | 1.69 (0.72 to 4.00) | 3.59 (1.11 to 11.64)e | NA | 0.135 | 1 (Ref) | 1.28 (0.81 to 2.02) |
| pulmonary mortalityb (n = 80) | 1 (Ref) | 1.57 (0.92 to 2.67) | 1.16 (0.35 to 3.78) | 1.65 (0.23 to 12.08) | NA | 0.174 | 1 (Ref) | 1.50 (0.90 to 2.48) |
| diabetes m. mortalityb (n = 164) | 1 (Ref) | 1.98 (1.30 to 3.01)d | 6.89 (4.13 to 11.49)c | 8.30 (3.58 to 19.23)c | 15.71 (4.97 to 49.64)c | <0.001 | 1 (Ref) | 3.06 (2.17 to 4.32)c |
| cirrhosis mortalityb (n = 102) | 1 (Ref) | 0.77 (0.39 to 1.52) | 1.37 (0.42 to 4.41) | 2.00 (0.28 to 14.50) | 6.84 (0.95 to 49.24) | 0.686 | 1 (Ref) | 0.95 (0.53 to 1.69) |
Values expressed as HR (95% CI). CHD, coronary heart disease; diabetes m., diabetes mellitus; ref, reference; NA, not applicable.
a
All-cause mortality and CV mortality were adjusted for age, gender, BMI, total cholesterol, hypertension, diabetes mellitus, smoking status, and eGFR categories.
b
Non-CV mortality was adjusted for age, gender, and eGFR categories.
c
P < 0.001.
d
P < 0.01.
e
P < 0.05.