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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Nat Struct Mol Biol. 2011 Apr 10;18(5):556–563. doi: 10.1038/nsmb.2046

Figure 2. Ligand-induced domain-domain interactions within the RXR-VDR heterodimer complex.

Figure 2

Figure 2

Figure 2

Figure 2

Differential HDX data mapped onto RXR-VDR docking model demonstrates (a) 1,25D3 (Supplementary Tables 1b(ii),and 1c(ii)) (b) 9-cis-RA (Supplementary Tables 1b(iii) and 1c(iii)) induced conformational changes of the RXR-VDR heterodimer complex as shown by comparing the deuterium incorporation of both receptors in the absence presence of ligands. (c) 1,25D3 induced conformational changes of the RXR-VDR heterodimer complex bound by 9-cis-RA (Supplementary Tables 1b(iv) and 1c(iv)). (d) 9-cis-RA induced conformational changes of the RXR-VDR heterodimer complex when bound to 1,25D3 (Supplementary Tables 1b(v) and 1c(v)).