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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Nat Cell Biol. 2011 Apr 10;13(5):599–610. doi: 10.1038/ncb2213

Figure 6. I Lack of HORMAD1 allows survival of oocytes in the SC-defective Spo11−/− mutant.

Figure 6

a, NOBOX (postnatal oocyte marker) was detected by IF on cryosections of ovaries from 6-weeks-old mice. DNA was detected by DAPI. Oocytes in primordial (pd), primary (pr) and secondary (s) follicular stages are shown in WT, Hormad1−/− and Hormad1−/− Spo11−/− ovaries. In the SC-defective Spo11−/− mutant, oocyte numbers are strongly reduced. A lower magnification section of a Spo11−/− ovary is shown to better illustrate the absence of oocytes. Bars, 50 μm. b, Sum of oocyte numbers on every tenth section of sectioned-through ovary pairs at the indicated ages. Each data point represents a mouse. c, Fraction of apoptotic oocytes in the ovaries of 1-day-old (1 dpp) mice of indicated genotypes. Horizontal lines show medians in b and c.