. 2010 Dec 14;18(6):1657–1664. doi: 10.1245/s10434-010-1451-z

Table 3.

Lymph node status and overall and disease-free survival for 1411 cT_1-2 breast cancer patients (from 7 Dutch hospitals operated between 2000 and 2003) in a hospital-only adjusted model, after additional adjustment for age, tumor size, and BR grade and after additional adjustment for adjuvant treatment

	No. of patients	Follow-up^a	No. events	Incidence rate^b	Adjusted model 1^c		Adjusted model 2^d		Adjusted model 3^e
	No. of patients	Follow-up^a	No. events	Incidence rate^b	Hazard ratio (95% CI)	P	Hazard ratio (95% CI)	P	Hazard ratio (95% CI)	P
Disease-free survival
All	1411	8182	305	37.28
_pN₀	922	5418	174	32.12	1.00 (referent)		1.00 (referent)		1.00 (referent)
_pN_1micro	103	621	16	25.77	0.78 (0.46–1.32)	.36	0.84 (0.49–1.43)	.52	0.96 (0.56–1.67)	.90
_pN_1a	285	1626	75	46.13	1.47 (1.12–1.92)	.006	1.35 (1.02–1.79)	.04	1.64 (1.19–2.27)	.003
_pN_≥1b	101	518	40	77.22	2.52 (1.78–3.57)	<.001	2.29 (1.60–3.29)	<.001	2.95 (1.98–4.42)	<.001
Overall survival
All	1411	8676	184	21.21
_pN₀	922	5720	88	15.38	1.00 (referent)		1.00 (referent)		1.00 (referent)
_pN_1micro	103	642	9	14.02	0.87 (0.44–1.73)	.69	0.99 (0.49–1.98)	.97	1.18 (0.58–2.39)	.65
_pN_1a	285	1733	57	32.89	2.20 (1.57–3.07)	<.001	1.99 (1.41–2.82)	<.001	2.47 (1.69–3.63)	<.001
_pN_≥1b	101	582	30	51.55	3.43 (2.25–5.22)	<.001	3.42 (2.21–5.30)	<.001	4.36 (2.70–7.04)	<.001

Median follow-up 6.4 years

CI confidence interval

^aFollow-up time in years (may not total due to rounding)

^bIncidence rate per 1000 women per year

^cAdjusted by Cox regression analysis for hospital

^dAdditionally adjusted by Cox regression analysis for age, age², tumor size (for overall survival also tumor size²), and BR grade

^eAdditionally adjusted by Cox regression analysis for radiotherapy, hormonal therapy, and chemotherapy