Table 4.
Toxicity.
| Patient number | Infectious complications | GI mucositis | Liver, transaminitis (hyperbilirubinemia) | Metabolic/renal | Other |
|---|---|---|---|---|---|
| 1 | Grade 4, F&N | Grade 3 | Grade 3 (Grade 3) | Grade 4 (elevated BUN/Creatinine) |
Neuro: Grade 3, Altered mental status Cardiovascular: Grade 4, Hypotension Pulmonary: Grade 4, Respiratory failure Skin: Grade 4, TEN |
| 2 | Grade 3, F&N | Grade 3 | |||
| 3 | Grade 3, F&N | Grade 3 | Grade 3 | ||
| 4 | Grade 3, F&N, Herpetic stomatitis | Grade 3 | Endo: Exacerbation of baseline panhypopituitarism | ||
| 5 | Grade 3, F&N | ||||
| 6 | Grade 3, F&N, Serratia UTI | Grade 3 | Grade 4, Hypokalemia | CV: Grade 1, Prolonged QTC Neuro: Grade 3, Hearing loss |
|
| 7 | Grade 3, Fever, sepsis with Pseudomonas and Klebsiella | Grade 3 | |||
| 8 | Grade 3, F&N, UTI with Vancomycin-resistant enterococcus | Grade 3 | Grade 2 | Neuro: Grade 2, Self-resolved seizure | |
| 9 | Grade 3, F&N | Grade 3 | |||
| 10 | Grade 1, Decreased GFR | Neuro: Grade 1, High-frequency hearing loss |
|||
| 11 | Grade 3, F&N, Eenterococcus UTI |
Grade 3 | |||
| 12 | Grade 1, Hypomagnesemia | Neuro: Grade 1, High frequency hearing loss |
|||
| 13 | Grade 3, Pneumonia | Grade 3 | Grade 1, Hypokalemia Grade 3, Hyponatremia (not SIADH) | ||
| 14 | Grade 2, Fever Grade 3, F&N |
Grade 2 (Grade 3) | Neuro: Grade 4, Status epilepticus | ||
| 15 | Grade 1, Hypomagnesemia | ||||
| 16 | |||||
| 17 | Grade 3, F&N | Grade 1, Hypomagnesemia | |||
| 18 | Grade 3, Zoster infection |
F&N: Fever and neutropenia, UTI: Urinary tract infection, GFR: Glomerular filtration rate, SIADH: Syndrome of inappropriate antidiuretic hormone hypersecretion, TEN: Toxic epidermal necrolysis.