Figure 1.

Growth of brain tumor cell lines is selectively inhibited by nanocurcumin via programmed cell death and cell cycle arrest. MTS assays performed on brain tumor cell lines DAOY (A), D283Med (B), U87 (D), JHH-GBM14 (E) and HSR-GBM1 (F) showed significant growth reduction after treatment over the period of time indicated. This was due to both apoptotic induction (G–I) and G₂/M cell cycle arrest (J–L). However, the non-neoplastic NIH-3T3 line instead showed greater growth after nanocurcumin treatment (C). Statistical significance was calculated using the final time points in (A–F). *p < 0.05, **p < 0.01, ***p < 0.001 compared to vehicle.