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. 2011 Mar 1;11(5):464–473. doi: 10.4161/cbt.11.5.14410

Figure 3.

Figure 3

The IGF-1R pathway is attenuated after nanocurcumin treatment in medulloblastoma cells. DAOY (A) cells treated with the indicated concentrations of curcumin showed decreased transcript levels of IGF-1, IGF-2 and IGF-1R. *p < 0.05, **p < 0.01, ***p < 0.001 compared to vehicle control. Lysates from DAOY (B) cells treated for 26 hours with vehicle or the indicated nanocurcumin concentrations show reduction in p-IGF-1Rβ (Tyr 1135/1136) and IGF-1Rβ protein levels. (C) p-STAT3 (Tyr 705) levels were reduced following curcumin nanoparticle treatment in DAOY cells. Normalized intensities measured by densitometry of two independent experiments are depicted as bar graphs (B and C, right graphs).