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Members of TNF superfamily are important regulators of autoimmune diseases. This cartoon illustrates that signalling via CD70 (a), CD30 (b), CD40 (c), CD134 (d), CD137 (e), Fas (f), TNFR (g), and TRAIL (h) elicits both disease promoting as well as disease alleviating effects. The importance of TNF superfamily in autoimmune diseases is further corroborated in mice deficient in CD137 (MRL/lpr/CD137-/-) (e), Fas (f) and TNFR1 (g), which show increased disease severity and mortality.
