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Potential biosynthetic pathways of NMSal, a parkinsonian neurotoxin: the condensation of dopamine (a neurotransmitter) with acetaldehyde (an alcohol metabolite) produces Sal that can be converted to NMSal by N-methytransferase; and the condensation of epinine that can be formed from dopamine via N-methylation with acetaldehyde produces NMSal.
