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Pro- and antiaging factors.
| Pro-aging | Antiaging |
|---|---|
| Reactive O2 (ROS) | Klotho hormone |
| Hyperperoxides | Melatonin hormone |
| DNA damage | Sirtuins |
| Ultraviolet light | WNT |
| Telomere attrition | Dietary/Calorie Restriction |
| WNT pathway | Antioxidants |
| Increased target of rapamycin (TOR) activation | Resveratrol (Sirtuin activator) |
| Reduced heat shock protein function | Reduced TOR and insulin |
| Defective lysosomes | Sestrins |
