Table 2.
Summary of factors in Post-MI remodeling and heart failure.
Parameter of remodeling | Effects on the heart |
---|---|
Changes in Myocytes | Myocyte hypertrophy |
Fetal gene expression | |
Increased myocyte length | |
Decreased myocyte numbers | |
Increased myocyte cell death | |
Changes in cardiac morphology | Left ventricular dilatation |
Increased extracellular matrix | |
Increased spherical shape | |
Increased wall thinning | |
Changes in left ventricular function | Increased oxygen consumption |
Increased adrenergic response | |
Increased end systolic and diastolic dysfunction |