TABLE 3 .
Characteristics of isolates marked by the presence of a single virulence or fitness gene
| Gene | Avg no. of virulence genes present in isolatea |
ΔVFb | Avg % change in gene prevalencec |
t test result ford: |
||
|---|---|---|---|---|---|---|
| Positive | Negative | Bladder | Kidney | |||
| tosA | 11.2 | 5.4 | 5.9 | 34.7 | <0.0001 | 0.0071 |
| picU | 11.2 | 5.4 | 5.8 | 34.6 | <0.0001 | NS |
| hlyA | 10.1 | 4.9 | 5.2 | 30.2 | NS | NS |
| cnf1 | 10.1 | 5.8 | 4.3 | 23.7 | NS | NS |
| sat | 9.5 | 5.0 | 4.5 | 25.2 | NS | NS |
| hma | 9.4 | 4.0 | 5.4 | 31.6 | <0.0001 | 0.0074 |
| tsh | 9.4 | 3.9 | 5.5 | 32.1 | <0.0001 | NS |
| iroN | 9.0 | 5.3 | 3.7 | 19.5 | NS | NS |
| iha | 9.0 | 4.9 | 4.1 | 22.1 | NS | NS |
| papA | 9.0 | 4.2 | 4.8 | 26.9 | 0.014 | NS |
| ireA | 8.7 | 6.1 | 2.7 | 11.8 | 0.0002e | 0.0155e |
| iutA | 8.7 | 4.6 | 4.1 | 22.1 | 0.0405e | NS |
| chuA | 8.4 | 2.4 | 6.0 | 35.4 | 0.0003 | NS |
| fyuA | 8.1 | 1.7 | 6.4 | 38.6 | 0.0017 | NS |
| fimA | 6.6 | 6.6 | 0.0 | −7.5 | ||
Average number of the 15 virulence factors present in isolates that contain (positive) or lack (negative) the indicated gene.
ΔVF, difference in the number of virulence factors between positive and negative.
The percentage change in gene prevalence of all 15 genes is averaged for each group.
Data in Fig. 2B and C were grouped according to the presence or absence of each gene and reanalyzed; the P value of each group that was found to be significant is reported. NS, not significant.
These genes were found to be negatively correlated with CFU/g of tissue. The presence of ireA was found previously (44) to negatively correlate with lethality in a murine model of peritonitis.