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. 2011 May;79(5):1915–1926. doi: 10.1128/IAI.01270-10

Fig. 3.

Fig. 3.

Effect of IL-4 and IFN-γ deletion on ABPM pathology in C. neoformans-infected lungs. Photomicrographs are H&E-stained sections of C. neoformans-infected lungs from WT (A, D, and G), IL-4−/− (B, E, and H), and IFN-γ−/− (C, F, and I to K) mice at 5 wpi. Low-power images (A, B, and C) demonstrate differences in the extent of inflammatory responses and consolidation of lung tissue (10× objective). High-power images (D, E, and F) of the boxed areas demonstrate cellular composition and differences in Mac morphology (40× objective). Note the absence of microbe in IL-4−/− lungs and the increased microbial presence and accumulation of eosinophilic deposits in the Mac in IFN-γ−/− lungs. High-power images of airway sections (G, H, and I) demonstrate differences in airway epithelium. Note the presence of eosinophilic inclusions in the epithelial cells of IFN-γ−/− mice (I). Severe pulmonary pathology in IFN-γ−/− lungs is highlighted by the formation of cryptococcomas (J, 10× objective), the presence of eosinophilic crystals in the airway lumen (K, 40× objective, red arrowheads), and the secretion of eosinophilic inclusions in the airway lumen, or hyalinosis (K, green arrows).