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Inability of plzA mutant cells to complete mouse-tick-mouse infection cycle
| Type of strain | Dose | % of: |
No. of viable spirochetes/tick | No. of nymphs/mouse | No. of mice infected/total | |
|---|---|---|---|---|---|---|
| Mice infected | Ticks positive | |||||
| Wild type | 5 × 104 | 100 | 95 | 3,947 ± 725 | 10 | 3/3 |
| plzA mutant | 5 × 106 | 100 | 55 | 20a | 30 | 0/5 |
| Complemented plzA+ | 5 × 104 | 100 | 100 | 3,006 ± 537 | 10 | 5/5 |
plzA-infected ticks had ≤20 spirochetes/tick (n = 10).
