Fig. 2.

IFNAR^−/− mice are less susceptible than WT mice to lethal challenge with the Y strain of T. cruzi. WT and IFNAR^−/− mice were infected with 10⁶ (A and B) or 10⁸ (C and D) Y strain T. cruzi parasites, and parasitemia (A and C) and survival (B and D) were monitored over the course of infection. A representative of two independent experiments is shown here. Results for WT and IFNAR^−/− mice are not statistically different, with the exception of panel D data, where the P value from the log rank test is reported.