Table 3.
WT and IFNAR−/− mice differ in the levels of plasma cytokines induced in response to T. cruzi infectiona
| Analyte | Avg concn (pg/ml) ± SEM for: |
P | |
|---|---|---|---|
| WT mice | IFNAR−/− mice | ||
| MCP-1 | 2,713 ± 101.4 | 836.3 ± 171.9 | 0.0025 |
| IL-10 | 1,187 ± 29.6 | 859.0 ± 31.8 | 0.0048 |
| MCP-5 | 580.0 ± 43.5 | 214.0 ± 40.5 | 0.0086 |
| VEGF | 582.7 ± 18.3 | 425.7 ± 3.7 | 0.0138 |
| MCP-3 | 4,527 ± 288.7 | 1,880 ± 127.7 | 0.0139 |
| MIP-1β | 575.7 ± 27.6 | 325.3 ± 44.7 | 0.0176 |
| Stem cell factor | 852.7 ± 52.1 | 542.7 ± 51.3 | 0.0241 |
| Leukemia inhibitory factor | 766.7 ± 20.5 | 652.3 ± 23.4 | 0.0348 |
a
Multianalyte profiling was used to measure plasma levels for 58 proteins in WT and IFNAR−/− mice 13 days after T. cruzi infection. Values are presented for the 8 proteins that are significantly different (P < 0.05) between WT and IFNAR−/− mice (n = 3 mice).