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. 2011 May;55(5):1937–1945. doi: 10.1128/AAC.01468-10

Fig. 3.

Fig. 3.

Effect of tomatidine on the biosynthesis of macromolecules in HQNO-treated S. aureus. (A to D) The effect of control antibiotics at approximately four times the MIC on the biosynthesis of proteins (chloramphenicol [CHL], 64 μg/ml), DNA (norfloxacin [NOR], 4 μg/ml), RNA (rifampin [RIF], 0.06 μg/ml), and cell wall peptidoglycan synthesis (vancomycin [VAN], 4 μg/ml) was evaluated for strain ATCC 29213. (E) Effect of TO at 125 μg/ml on the biosynthesis of macromolecules in ATCC 29213. (F) Effect of different concentrations of TO on the biosynthesis of macromolecules in ATCC 29213 in the presence of HQNO at 20 μg/ml. Significant decreases of the biosynthesis of one macromolecule compared to that of all three others are indicated (*, P < 0.05 by one-way analysis of variance [ANOVA] with Dunnett's post test for A to E and two-way ANOVA with a Bonferroni's post test for F). Results are from three independent experiments and are expressed as percentages of the incorporation of radiolabeled molecules by untreated (A to D), DMSO-treated (E), or HQNO-treated bacteria (F).