Table 1.
Susceptibility of normal and SCV S. aureus strains to tomatidine, tomatine, and control antibiotics with or without the presence of HQNO
| Straina | MICb (μg/ml) |
|||||||
|---|---|---|---|---|---|---|---|---|
| HQNO | TO | TN | GEN | VAN | ERY | CIP | OXA | |
| ATCC 29213 | − | >16 | >16 | 1 | 2 | 0.12–0.25 | 0.5 | 0.12–0.25 |
| + | 0.12–0.25 | >16 | 4 | 2 | 0.25 | 0.25 | 0.12 | |
| Newbould | − | >16 | >16 | 0.5–1 | 1 | 0.25 | 0.25–0.5 | 0.06–0.12 |
| NewbouldΔhemB | − | 0.12 | >16 | 4–8 | 2 | >16 | 0.12–0.25 | 0.03–0.06 |
| CF07-L | − | >16 | >16 | 1–2 | 2 | 0.25 | 0.5 | 0.06–0.12 |
| + | 0.5 | >16 | 4 | 2 | 0.25 | 0.25 | 0.06–0.12 | |
| CF07-S | − | 0.12 | >16 | 8 | 2 | 0.12 | 0.12 | 0.06–0.12 |
| + | 0.12 | >16 | 4–8 | 2 | 0.06–0.12 | 0.12 | 0.06–0.12 | |
| CF1A-L | − | >16 | >16 | 1–2 | 1–2 | 0.25 | 0.5 | 0.25 |
| CF1D-S | − | 0.12 | >16 | 8 | 2 | 0.12 | 0.12 | 0.06–0.12 |
a
ATCC 29213, Newbould, CF07-L, and CF1A-L are normal strains, whereas NewbouldΔhemB, CF07-S, and CF1D-S are SCVs.
b
4-Hydroxy-2-heptylquinoline-N-oxide (HQNO) was used at 20 μg/ml. TO, tomatidine; TN, tomatine; GEN, gentamicin; VAN, vancomycin; ERY, erythromycin; CIP, ciprofloxacin; OXA, oxacillin.