Table 2.
Effects of bafilomycin A and chloroquine on intracellular levels of cPrMEDAP-Phe and cPrMEDAP in SiHa cells
| Time (min) | Treatment of SiHa cells | Intracellular concn (μM)a (fold change relative to untreated control) |
|
|---|---|---|---|
| cPrPMEDAP | cPrPMEDAP-Phe | ||
| 30.0 | Control | 199.2 ± 21.1 | 38.0 ± 4.5 |
| 100 nM bafilomycin | 372.6 ± 42.4 (1.9) | 303.7 ± 21.0 (8.0) | |
| 100 μM chloroquine | 391.2 ± 29.6 (2.0) | 306.7 ± 18.9 (8.0) | |
| 60.0 | Control | 337.3 ± 32.0 | 54.3 ± 3.0 |
| 100 nM bafilomycin | 482.5 ± 51.5 (1.4) | 296.4 ± 23.1 (5.5) | |
| 100 μM chloroquine | 709.3 ± 59.1 (2.1) | 299.7 ± 27.6 (5.5) | |
| 120.0 | Control | 476.1 ± 56.8 | 59.0 ± 5.1 |
| 100 nM bafilomycin | 642.8 ± 78.4 (1.3) | 195.7 ± 26.0 (3.3) | |
| 100 μM chloroquine | 895.1 ± 91.1 (1.9) | 175.9 ± 23.4 (3.0) | |
a
The results represent the means ± standard deviations of two independent experiments.