Table 4.
Plasma solithromycin trough concentrations in multiple-dose protocols
| Dose cohort | Mean solithromycin Cmina (% CV) |
|||||
|---|---|---|---|---|---|---|
| Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 7 (h 24) | |
| 200 mg (n = 5) | 0.0164 (27.6) | 0.0153 (25.6) | 0.0159 (41.3) | 0.0148 (29.4) | 0.0159 (22.2) | 0.0195 (31.9) |
| 400 mg (n = 10) | 0.0671 (71.7) | 0.0946 (81.8) | 0.118 (83.6) | 0.14 (74.1) | 0.153 (80.1) | 0.225 (67.4) |
| 600 mg (n = 10) | 0.180 (60.6) | 0.210 (57.0) | 0.263 (54.9) | 0.261 (73.6) | 0.273 (59.7) | 0.303 (44.6) |
a
Plasma Cmins are reported in μg/ml. Values that were below the limit of quantitation (BLQ) of 0.01 μg/ml were treated as missing.