Table 5.
Dose proportionality results for solithromycin in plasmaa
| Dosing day | Pharmacokinetic parameter | Slope (b) | SE | 95% CI for slope |
|---|---|---|---|---|
| 1 | Cmax (μg/ml) (n = 25) | 1.6046 | 0.4823 | (0.7780, 2.4312) |
| AUC0–t (μg · h/ml) (n = 25) | 1.7765 | 0.5042 | (0.9123, 2.6406) | |
| AUC0–∞ (μg · h/ml) (n = 25) | 2.0375 | 0.4686 | (1.2312, 2.8438) | |
| 7 | Cmax (μg/ml) (n = 25) | 1.6567 | 0.3285 | (1.0937, 2.2198) |
| AUCτ (μg · h/ml) (n = 25) | 1.9043 | 0.3713 | (1.2679, 2.5407) |
a
The statistical analyses were performed using the SAS mixed procedure. A linear regression model with ln-transformed parameter and ln-transformed dose was used. Dose proportionality was not rejected if the 95% CI for the slope included the value of 1.