Table 1.

Analysis of NS5A-CypA, CypB, and CypD complex prevention (by ELISA) and anti-PPIase activities of sanglifehrins and CsA

Cyclophilin inhibitor	NS5A-CypA disruption (IC50) (μM)	CypA PPIase inhibition (Ki) (nM)	NS5A-CypB disruption (IC50) (μM)	CypB PPIase inhibition (Ki) (nM)	NS5A-CypD disruption (IC50) (μM)	CypD PPIase inhibition (Ki) (nM)
SfA	0.35 ± 0.11	2.4 ± 0.11	0.42 ± 0.09	2.1 ± 0.1	0.37 ± 1.2	2.4 ± 0.2
SfB	0.11 ± 0.02	0.32 ± 0.08	0.15 ± 0.02	0.20 ± 0.02	0.09 ± 0.03	0.3 ± 0.1
SfC	0.56 ± 0.04	6.8 ± 1.1	0.61 ± 0.04	5.4 ± 0.5	0.53 ± 0.05	5.1 ± 0.03
SfD	0.53 ± 0.02	6.9 ± 1.4	0.49 ± 0.03	5.8 ± 0.4	0.55 ± 0.04	6.1 ± 0.5
CsA	0.98 ± 0.08	9.7 ± 1.3	0.83 ± 0.05	9.2 ± 0.8	0.91 ± 0.7	9.4 ± 1.1