Table 1.
Cyclophilin inhibitor | NS5A-CypA disruption (IC50) (μM) | CypA PPIase inhibition (Ki) (nM) | NS5A-CypB disruption (IC50) (μM) | CypB PPIase inhibition (Ki) (nM) | NS5A-CypD disruption (IC50) (μM) | CypD PPIase inhibition (Ki) (nM) |
---|---|---|---|---|---|---|
SfA | 0.35 ± 0.11 | 2.4 ± 0.11 | 0.42 ± 0.09 | 2.1 ± 0.1 | 0.37 ± 1.2 | 2.4 ± 0.2 |
SfB | 0.11 ± 0.02 | 0.32 ± 0.08 | 0.15 ± 0.02 | 0.20 ± 0.02 | 0.09 ± 0.03 | 0.3 ± 0.1 |
SfC | 0.56 ± 0.04 | 6.8 ± 1.1 | 0.61 ± 0.04 | 5.4 ± 0.5 | 0.53 ± 0.05 | 5.1 ± 0.03 |
SfD | 0.53 ± 0.02 | 6.9 ± 1.4 | 0.49 ± 0.03 | 5.8 ± 0.4 | 0.55 ± 0.04 | 6.1 ± 0.5 |
CsA | 0.98 ± 0.08 | 9.7 ± 1.3 | 0.83 ± 0.05 | 9.2 ± 0.8 | 0.91 ± 0.7 | 9.4 ± 1.1 |