Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Physicochemical parametersa
| Cyclophilin inhibitor | Solubility (μM) | log D, pH 7.4 | HLM t1/2 (min) | MLM t1/2 (min) | Human hepatocyte t1/2 (min) |
|---|---|---|---|---|---|
| SfA | 45 | >4.6 | 7.9 | 4.0 | 145 |
| SfB | 16 | >4.5 | 7.0 | 2.4 | 156 |
| SfC | 10 | >4.2 | 3.4 | 11.0 | 40 |
| SfD | 25 | 4.1 | 4.4 | 9.1 | 54 |
Data are shown for solubility in PBS (pH 7.4), lipophilicity (log D, pH 7.4), and human (HLM) and mouse (MLM) microsome and hepatocyte stability (t1/2).
