Table 4.

Pharmacokinetic parameters after i.v. and p.o. dosing of CD1 mice^a

Cyclophilin inhibitor	Clearance (liter/h/kg)	t1/2 (h)	Vss (liter/kg)	AUClastb (h · ng/ml)		p.o. Cmaxc (ng/ml)	F (%)
				I.v.	P.o.
SfA	0.054	8.02	0.522	16,473	2,332	192	1.42
SfB	0.068	5.89	0.439	14,067	5,693	809	3.94
SfC	0.824	1.11	0.383	1,257	26	22	0.21
SfD	0.545	1.64	0.244	2,157	20	12	0.09

^aData were generated after analysis of whole-blood samples, following doses of 1 mg/kg i.v. and 10 mg/kg p.o. to CD1 mice.

^bAUC_last, area under the concentration-time curve.

^cC_max, maximum concentration of drug in serum.