Table 1.
A. fumigatus exhibits phase-dependent resistance to voriconazole
| Strain | 8 h |
12 h |
24 h |
||||||
|---|---|---|---|---|---|---|---|---|---|
| SMIC90 (ΔMICa) | Ala-Nap (RFU/mg) | ΔMDR4c | SMIC90 (ΔMICb) | Ala-Nap (RFU/mg) | ΔMDR4 | SMIC90 (ΔMICb) | Ala-Nap (RFU/mg) | ΔMDR4 | |
| Af293 | 0.5 (8) | 1,286 | 1 | 8 (16) | 618 | 3.89 | >256 (>512) | 402 | 2.35 |
| YHCF1 | 0.0625 (2) | 1,263 | 1 | 1 (16) | 573 | 4.37 | 256 (>512) | 697 | 3.38 |
| YHCF2 | 0.0625 (4) | 1,269 | 1 | 1 (16) | 609 | 2.31 | >256 (>512) | 264 | 2.72 |
| YHCF3 | 1.0 (4) | 1,153 | 1 | 32 (32) | 634 | 31.60 | >256 (>512) | 376 | 4.50 |
| YHCF4 | 0.125 (8) | 1,161 | 1 | 16 (128) | 498 | 65.10 | >256 (>512) | 346 | 14.80 |
| YHCF5 | 0.125 (8) | 16 (128) | >256 (>512) | ||||||
| YHCF6 | 0.125 (4) | 16 (128) | >256 (>512) | ||||||
| YHCF7 | 0.125 (8) | 8 (64) | >256 (>512) | ||||||
| YHCF8 | 0.0312 (4) | 4 (128) | >256 (>512) | ||||||
| YHCF9 | 0.0625 (4) | 16 (128) | >256 (>512) | ||||||
| YHCF10 | 0.0625 (4) | 32 (256) | >256 (>512) | ||||||
| YHCF11 | 0.0625 (8) | 8 (64) | >256 (>512) | ||||||
| YHCF12 | 0.0625 (4) | 8 (64) | >256 (>512) | ||||||
| YHCF13 | 0.0312 (4) | 4 (128) | >256 (>512) | ||||||
a
Fold change in the MIC following efflux pump inhibitor challenge.
b
Fold change in the MIC compared to the MIC for 8-h germling cells.
c
Fold change in expression of AfuMDR4 compared to 8-h germling cells.