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Proposed approach for the generation of neutrophil elastase-dependent host defense peptide prodrugs and its application to Ac-E4-A3–d-P18. Residue numbering used in the NMR studies is included as superscript numbers in the sequences of d-P18 and its propeptide; Ac indicates N-terminal acetylation, OH is a C-terminal carboxyl group, and NH2 is a C-terminal amide group.
