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(A) Structure of lacticin Q. fMet, formylmethionine. (B) The action mechanism of lacticin Q was determined previously and termed the huge toroidal pore model. Lacticin Q rapidly binds to the outer leaflet of the cell membrane and forms huge toroidal pores (pore diameter, 4.6 to 6.6 nm) accompanied by lipid flip-flop. Some lacticin Q molecules migrate from the outer to the inner leaflet of the membrane.
