Fig. 9.

Enzyme activities of mitochondrial respiratory chain complexes I to IV in cardiac and skeletal muscle, liver, and kidney of Himalayan marmots treated with metacavir (PNA), zidovudine (AZT), or water for 90 days. Mitochondria were then extracted as described in Materials and Methods. Results are expressed as means ± standard deviations. *, P < 0.05; **, P < 0.01 (compared to results for controls, by Dunnett's multiple-comparison test).