Table 1.

Activities of antimicrobial agents against 151 Nocardia isolates

Bacterium (no of isolates tested) and antimicrobial agent	MIC (μg/ml)			Susceptibility (%)a
	Range	50%	90%	S	I	R
N. brasiliensis (60)
Amoxicillin-clavulanic acid	0.5–32	1	2	59 (98)		1 (2)
Cefoxitin	1–>128	2	8
Ceftriaxone	0.5–32	2	4	57 (95)	3 (5)	0 (0)
Meropenem	0.5–8	2	4
Ertapenem	0.25–8	4	8
Imipenem	0.5–>32	2	>32	28 (47)	3 (5)	29 (48)
Doripenem	0.5–8	2	4
Azithromycin	16–>128	32	>128
Ciprofloxacin	0.5–8	8	8	1 (2)	0 (0)	59 (98)
Nemonoxacin	0.12–1	0.25	0.5
Gemifloxacin	0.06–2	0.25	0.5
Levofloxacin	1–>16	4	8
Moxifloxacin	0.12–2	1	1
Linezolid	1–16	4	8	59 (98)		1 (2)
Vancomycin	0.5–>128	128	>128
Daptomycin	64–>128	128	>128
Sulfamethoxazole	0.5–64	4	8	59 (98)		1 (2)
Amikacin	0.25–4	1	2	60 (100)		0 (0)
Tigecycline	0.25–1	0.25	1
N. cyriacigeorgica (24)
Amoxicillin-clavulanic acid	4–16	16	16	9 (38)	14 (58)	1 (4)
Cefoxitin	0.12–>16	4	16
Ceftriaxone	0.25–16	2	8	23 (96)	1 (4)	0 (0)
Meropenem	1–4	4	4
Ertapenem	2–8	4	8
Imipenem	0.5–>4	1	2	24 (100)	0 (0)	0 (0)
Doripenem	1–8	4	4
Azithromycin	128–>128	>128	>128
Ciprofloxacin	0.12–128	16	64	0 (0)	0 (0)	24 (100)
Nemonoxacin	0.25–2	1	2
Gemifloxacin	2–8	2	4
Levofloxacin	8–>32	16	32
Moxifloxacin	2–4	4	4
Linezolid	2–16	4	4	23 (96)		1 (4)
Vancomycin	16–>128	128	>128
Daptomycin	128–>128	128	>128
Sulfamethoxazole	2–16	4	4	24 (100)		0 (0)
Amikacin	0.5–2	1	2	24 (100)		0 (0)
Tigecycline	0.5–4	2	4
N. farcinica (12)
Amoxicillin-clavulanic acid	0.5–8	1	4	12 (100)	0 (0)	0 (0)
Cefoxitin	0.5–>128	32	>128
Ceftriaxone	1–>64	32	64	3 (25)	5 (42)	4 (33)
Meropenem	0.5–>8	4	4
Ertapenem	0.5–>8	8	8
Imipenem	0.25–>4	1	2	12 (100)	0 (0)	0 (0)
Doripenem	0.25–>4	4	4
Azithromycin	128–>128	>128	>128
Ciprofloxacin	0.5–128	8	16	6 (50)	1 (8)	5 (42)
Nemonoxacin	0.03–1	0.25	1
Gemifloxacin	0.03–2	0.12	0.5
Levofloxacin	0.12–16	4	8
Moxifloxacin	0.06–8	1	2
Linezolid	1–4	4	4	12 (100)
Vancomycin	2–>128	128	>128
Daptomycin	64–>128	128	>128
Sulfamethoxazole	2–64	8	32	11 (92)		1 (8)
Amikacin	1–4	1	4	12 (100)		0 (0)
Tigecycline	0.25–8	1	8
N. beijingensis (9)
Amoxicillin-clavulanic acid	1–32			4 (44)	4 (44)	1 (11)
Cefoxitin	1–>4
Ceftriaxone	0.25–16			7 (78)	2 (22)	0 (0)
Meropenem	0.25–2
Ertapenem	2–4
Imipenem	0.5–>8			5 (56)	4 (44)
Doripenem	1–2
Azithromycin	64–>128
Ciprofloxacin	2–128			0 (0)	4 (44)	5 (56)
Nemonoxacin	0.5–8
Gemifloxacin	0.25–16
Levofloxacin	4–16
Moxifloxacin	1–32
Linezolid	2–4			9 (100)
Vancomycin	128–>128
Daptomycin	64–>>128
Sulfamethoxazole	1–4			9 (100)		0 (0)
Amikacin	0.12–0.5			8 (89)		1 (11)
Tigecycline	0.12–8
N. otitidiscaviarum (8)
Amoxicillin-clavulanic acid	32–128			0 (0)	0 (0)	8 (100)
Cefoxitin	64–>128
Ceftriaxone	16–>128			0 (0)	1 (13)	7 (87)
Meropenem	4–>32
Ertapenem	16–>32
Imipenem	16–>32			0 (0)	0 (0)	8 (100)
Doripenem	4–>32
Azithromycin	0.5–>128
Ciprofloxacin	2–16			0 (0)	3 (37)	5 (63)
Nemonoxacin	0.5–2
Gemifloxacin	0.5–4
Levofloxacin	1–8
Moxifloxacin	0.25–4
Linezolid	2–4			8 (100)
Vancomycin	128–>128
Daptomycin	64–128
Sulfamethoxazole	4–32			8 (100)		0 (0)
Amikacin	0.5–4			8 (100)		0 (0)
Tigecycline	0.5–2
N. nova (8)
Amoxicillin-clavulanic acid	8–64			1 (13)	3 (38)	4 (50)
Cefoxitin	2–16
Ceftriaxone	2–16			7 (87)	1 (13)	0 (0)
Meropenem	0.12–2
Ertapenem	0.5–4
Imipenem	0.03–1			8 (100)	0 (0)	0 (0)
Doripenem	0.25–2
Azithromycin	0.25–>128
Ciprofloxacin	4–16			0 (0)	0 (0)	8 (100)
Nemonoxacin	0.25–1
Gemifloxacin	0.5–2
Levofloxacin	2–>32
Moxifloxacin	0.5–4
Linezolid	12			8 (100)
Vancomycin	32–>128
Daptomycin	64–>128
Sulfamethoxazole	4–32			8 (100)		0 (0)
Amikacin	0.12–32			7 (87)		1 (13)
Tigecycline	0.25–8
N. asiatica (7)
Amoxicillin-clavulanic acid	16–64			0 (0)	1 (14)	6 (86)
Cefoxitin	0.5–2
Ceftriaxone	0.5–1			7 (100)	0 (0)	0 (0)
Meropenem	0.5–2
Ertapenem	1–4
Imipenem	0.5–1			7 (100)	0 (0)	0 (0)
Doripenem	1–2
Azithromycin	>128
Ciprofloxacin	64–128			0 (0)	0 (0)	7 (100)
Nemonoxacin	16
Gemifloxacin	16–32
Levofloxacin	>32
Moxifloxacin	1–32
Linezolid	1–4			7 (100)
Vancomycin	128–>128
Daptomycin	128–>128
Sulfamethoxazole	2–8			7 (100)		0 (0)
Amikacin	0.12–0.25			7 (100)		0 (0)
Tigecycline	0.25–1
N. puris (6)
Amoxicillin-clavulanic acid	16			0 (0)	6 (100)	0 (0)
Cefoxitin	128–>128
Ceftriaxone	4–>128			1 (17)	0 (0)	5 (83)
Meropenem	2–4
Ertapenem	4–8
Imipenem	1–2			6 (100)	0 (0)	0 (0)
Doripenem	2–4
Azithromycin	4–>128
Ciprofloxacin	8			0 (0)	0 (0)	6 (100)
Nemonoxacin	0.5
Gemifloxacin	1
Levofloxacin	4–8
Moxifloxacin	2
Linezolid	2–4			6 (100)
Vancomycin	0.5–>128
Daptomycin	128–>128
Sulfamethoxazole	0.5–16			6 (100)		0 (0)
Amikacin	0.12–1			6 (100)		0 (0)
Tigecycline	0.25–2
Other Nocardia spp. (17)
Amoxicillin-clavulanic acid	1–64	8	32	10 (59)	3 (18)	4 (24)
Cefoxitin	0.12–32	4	16
Ceftriaxone	0.25–8	1	4	17 (100)	0 (0)	0 (0)
Meropenem	0.12–4	1	4
Ertapenem	0.25–16	2	8
Imipenem	0.12–32	0.5	2	16 (94)	0 (0)	1 (6)
Doripenem	0.12–4	2	4
Azithromycin	1–>128	>128	>128
Ciprofloxacin	0.25–128	8	16	4 (24)	1 (6)	12 (71)
Nemonoxacin	0.12–16	1	16
Gemifloxacin	0.06–32	2	32
Levofloxacin	0.25–>32	8	16
Moxifloxacin	0.25–32	4	32
Linezolid	0.5–4	2	4	17 (100)
Vancomycin	0.25–>128	128	>128
Daptomycin	0.5–>128	128	>128
Sulfamethoxazole	4–32	4	8	17 (100)		0 (0)
Amikacin	0.12–32	0.5	2	16 (94)		1 (6)
Tigecycline	0.06–4	0.5	2

^aS, susceptible; I, intermediate; R, resistant.