Table 1.
Activities of antipseudomonal agents against P. aeruginosa bloodstream isolates from Spanish hospitals
| Antibiotica | MIC50 (μg/ml) | MIC90 (μg/ml) | MIC range (μg/ml) | % S (% S according to according to EUCAST breakpoints)b | % I (% I according to according to EUCAST breakpoints)b | % R (% R according to according to EUCAST breakpoints)b |
|---|---|---|---|---|---|---|
| CAZ | 4 | 32 | 0.25–≥128 | 76.3 | 6.8 (0.0) | 16.9 (23.7) |
| FEP | 8 | 32 | 0.25–≥128 | 61.6 | 20.0 (0.0) | 18.4 (38.4) |
| ATM | 8 | 32 | 0.25–≥128 | 67.4 (1.6) | 21.6 (87.4) | 11.0 |
| PIP | 8 | 128 | 1–≥128 | 80.5 (65.8) | 19.5 (34.2) | |
| PIP-Tz | 8 | 128 | 1–≥128 | 86.3 (72.1) | 13.7 (27.9) | |
| IMP | 2 | 32 | 0.12–≥64 | 67.9 | 9.5 | 22.6 |
| MER | 1 | 16 | 0.06–≥64 | 77.4 (70.0) | 7.4 (14.8) | 15.2 |
| CIP | 0.25 | 32 | 0.03–≥32 | 71.6 (65.8) | 1.6 (5.8) | 26.8 (28.4) |
| LEV | 1 | 32 | 0.03–≥32 | 68.4 (62.6) | 2.6 (5.8) | 29.0 (31.6) |
| GEN | 2 | 64 | 0.06–≥64 | 78.9 | 2.1 (0.0) | 19.0 (21.1) |
| TOB | 0.5 | 64 | 0.06–≥64 | 81.6 | 1.1 (0.0) | 17.3 (18.4) |
| AMK | 4 | 8 | 0.12–≥128 | 98.4 (93.7) | 0.5 (4.7) | 1.1 (1.6) |
| COL | 0.5 | 1 | 0.03–8 | 96.8 (98.9) | 2.1 (0.0) | 1.1 |
a
CAZ, ceftazidime; FEP, cefepime; ATM, aztreonam; PIP, piperacillin; PIP-Tz, piperacillin-tazobactam; IMP, imipenem; MER, meropenem; CIP, ciprofloxacin; LEV, levofloxacin; GEN, gentamicin; TOB, tobramycin; AMK, amikacin; COL, colistin.
b
Percentage of isolates susceptible (S), intermediate (I), or resistant (R) according to CLSI breakpoints (5). When different, the corresponding percentages of S, I, and R isolates according to EUCAST breakpoints (www.eucast.org) are also indicated in parentheses for comparative purposes.