Table 1.
Nomenclature of commonly used/commercially available antiviral compounds
| Compound type and generic namea | Commercial name | Common abbreviation | Target |
|---|---|---|---|
| NRTIs | |||
| Azidothymidine or zidovudine | Retrovir | AZT | HIV-1 reverse transcriptase |
| Zalcitabine | Hivid | ddC | |
| Didanosine | Videx | ddI | |
| Lamivudine | Zeffix | 3TC | |
| Stavudine | Zerit | D4T | |
| Abacavir | Ziagen | ABC | |
| Emtricitabine | Emtriva | FTC | |
| NNRTIs | |||
| Nevirapine | Viramune | NVP | HIV-1 reverse transcriptase |
| Delavirdine | Rescriptor | DLV | |
| Efavirenz | Sustiva | EFV | |
| Etravirine | Intelence | ETV | |
| Tenofovir | Viread | TDF | |
| PIs | |||
| Amprenavir | Agenerase | APV | HIV-1 protease |
| Indinavir | Crixivan | IDV | |
| Nelfinavir | Viracept | NFV | |
| Atazanavir | Reyataz | ATV | |
| Lopinavir | Kaletra or Aluvia | LPV | |
| Saquinavir | Invirase or Fortovase | SQV | |
| Darunavir | Prezista | DRV | |
| Fosamprenavir | Lexiva or Telzir | FPV | |
| Ritonavir | Norvir | RTV | Targets HIV-1 protease and also inhibits cytochrome P450-3A4, which normally metabolizes protease inhibitors |
| INSTI | |||
| Raltegravir | Isentress | RAL | HIV-1 integrase |
| Binding and entry inhibitors | |||
| Maraviroc | Selzentry or Celsentri | MVC | CCR5 in its role as an HIV-1 coreceptor |
| Enfuvirtide | Fuzeon | T-20 | gp41-mediated fusion |
a
NRTI, nucleoside reverse transcriptase inhibitor; NNRTI, nonnucleoside reverse transcriptase inhibitor; PI, protease inhibitor; INSTI, integrase strand transfer inhibitor.