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Correlation of cell growth inhibition (EC50) and binding to recombinant parasite MetRS. Binding was determined by the shift in the melting temperature (ΔTm) of the protein in the presence of compounds. R2 values are 0.92 (P < 0.0001) for T. brucei (solid diamonds) and 0.79 (P < 0.0001) for T. cruzi (open circles). Numeric data for this series of compounds are presented in Table 1.
