Table 5.
Relationship between 2′-C-MeGTP concentration in liver to 2′-C-MeG exposure in plasma following a single oral dose of INX-08189 in rats
| INX-08189 dose (mg/kg) | N | Liver 2′-C-MeGTPaC24 (ng/g) | Plasma 2′-C-MeGb AUC0-24 (ng · h/ml) |
|---|---|---|---|
| 3 | 6 | 159 | 73.4 |
| 5 | 2 | 412 | 145.6 |
| 10 | 2 | 658 | 322.5 |
| 25 | 2 | 774 | 707.9 |
| 30 | 3 | 1,263 | 1,024.3 |
| 50 | 3 | 2,880 | 2,085.3 |
| 150 | 3 | 7,130 | 3,979.2 |
| 300 | 3 | 10,610 | 4,309.3 |
a
Mean concentrations for 2′-C-MeGTP measured at 24 h.
b
Area under the curve values covering 0 to 24 h (AUC0-24) were calculated from average 2′-C-MeG plasma concentrations measured at six time points.