Table 2.

Anti-HIV-1 efficacy of 4′-C-methyl- and 4′-C-ethyl-2′-deoxyadenosine against vectors with selected NRTI resistance mutations in HOS cells

Strain	4′-C-Me-2′-dA		4′-C-Et-2′-dA
	EC50 (nM)	Fold changea	EC50 (nM)	Fold changea
Wild type	63 ± 7		221 ± 3
M184V	>10,000	>150	>10,000	>45
AZT-R	64 ± 5	1.0	869 ± 55	3.9
SSGR + T215Y	25 ± 9	0.38	700 ± 100	3.2
Q151M complex	111 ± 8	1.7	520 ± 25	2.3

^aVersus wild type.