Fig. 2.

ORF map and genetic organization of ICESp2905 from S. pyogenes strain iB21 (accession no. FR691055), and its alignment with the ORF map of C. difficile ICECd630 (accession no. AM180355). The ORFs, indicated as arrows pointing in the direction of transcription, are numbered consecutively (orf1 to orf61 in ICESp2905, with some predicted functions reported in Table S2 in the supplemental material; and orf1 to orf33 in ICECd630). ICECd630 ORFs and related ORFs in ICESp2905 are depicted as yellow arrows. ICESp2905 ORFs of the erm(TR) fragment and the tet(O) fragment are depicted as red and blue arrows, respectively, except for erm(TR) (striped red) and tet(O) (checkered blue). Other ICESp2905 ORFs are depicted as white arrows. Gray areas between ORF maps denote significant DNA identities (>70%) as indicated.