Table 2.
Distribution of MICs and AUC/MIC ratios by Candida species
| Candida species | No. of isolates | MIC distribution (mg/liter) |
AUC/MIC ratioa |
|||||
|---|---|---|---|---|---|---|---|---|
| 50% | 90% | Minimum | Maximum | Median | Minimum | Maximum | ||
| C. albicans | 218 | ≤0.004 | 0.008 | ≤0.002 | 0.016 | 24,306 | 5,851 | 98,716 |
| C. tropicalis | 99 | 0.008 | 0.016 | ≤0.002 | 1 | 11,962 | 150.4 | 50,954 |
| C. parapsilosis | 77 | 0.5 | 1.0 | 0.12 | 2.0 | 196.2 | 41.28 | 2,534 |
| C. glabrata | 62 | 0.008 | 0.016 | ≤0.002 | 0.016 | 12,495 | 4,917 | 38,476 |
| C. krusei | 17 | 0.12 | 0.125 | 0.03 | 0.25 | 1,165 | 564.8 | 2,896 |
| Other Candida species | 20 | 0.12 | 0.5 | <0.004 | 1.0 | 960.6 | 98.08 | 38,620 |
| Total | 493 | 0.008 | 0.5 | ≤0.002 | 2.0 | 15,511 | 41.28 | 98,716 |
a
AUC/MIC ratios were based on AUC values that were calculated using individual predicted steady-state AUC values for patients for whom PK data were collected and population mean predicted steady-state AUC values for patients for whom PK data were not collected.