Fig. 4.

Comparison of relative fitness between the consensus C (conC) RT, the MJ4 RT, and the MJ4 RT containing the 296T point mutation. The bars represent the averages of results from five independent experiments, and the error bars represent 1 standard deviation. “ND” signifies that the experiment was not done, and “NI” means that the virus was not infectious in this assay. An asterisk marks a difference between the WT and the mutant relative fitnesses according to the Mann-Whitney rank sum test, where a P value of less than 0.05 is defined as significant.