Table 1.
Percent identities between domains of MRSA PK and the corresponding domains of human PK isoforms and PKs from E. faecium, S. pneumoniae, E. coli, and P. aeruginosaa
| PK | % identity (% similarity) |
||
|---|---|---|---|
| A domain | B domain | C domain | |
| Human | |||
| M1 | 57 (74) | 40 (57) | 30 (50) |
| M2 | 57 (74) | 40 (57) | 35 (55) |
| LR1 | 56 (70) | 36 (56) | 33 (55) |
| LR2 | 56 (70) | 36 (56) | 33 (55) |
| Bacterial | |||
| E. faecium PK | 78 (85) | 60 (77) | 57 (68.0) |
| S. pneumoniae PK | 48 (63) | 37 (66) | 40 (57) |
| E. coli PK1 | 63 (77) | 41 (62) | 37 (56) |
| E. coli PK2 | 48 (67) | 35 (55) | 33 (48) |
| P. aeruginosa PK1 | 47 (67) | 28 (55) | 32 (55) |
| P. aeruginosa PK2 | 47 (66) | 32 (52) | 31 (47) |
a
GenBank accession numbers are YP_041163.1 for MRSA PK, NP_872270 for human PK isoform M1, AAA36449.1 for human PK isoform M2, NM_000298 for human PK isoform LR1, NM_181871.3 for human PK isoform LR2, NP_814779.1 for E. faecium PK, YP_816275.1 for S. pneumoniae PK, NP_310410 for E. coli isoform PK1, NP_310591 for E. coli isoform PK2, NP_250189.1 for P. aeruginosa isoform PK1, and NP_253019.1 for P. aeruginosa isoform PK2.