Fig. 1.

Effect of a single i.n. treatment with various doses of DEF201 on disease of hamsters infected with YFV. Ribavirin was included as a positive control and was administered i.p. b.i.d. for 7 days beginning at −4 h dpi at a dose of 75 mg/kg/day. Disease parameters include survival (A), percent weight change (B), serum ALT level on 6 dpi (C), and virus titer (quantified as CCID₅₀s/g tissue or ml serum) in the liver and serum on 4 dpi (D). Dashed and solid gray lines in panel D, limits of detection of the liver and serum virus assays, respectively. ***, P < 0.001 compared with empty vector treatment; **, P < 0.01 compared with empty vector treatment; *, P < 0.05 compared with empty vector treatment.