Table 2.
Cohort Studies Evaluating Ultrasound and Alpha-fetoprotein (AFP) for the Detection of Hepatocellular Carcinoma (HCC)
| Study | No. of patients | Mean follow-up (months) | Surveillance method | HCC detected, n (%) | Early-stage HCC, n (%) |
|---|---|---|---|---|---|
| Cottone M, et al.66 | 147 | 24 | AFP and ultrasound | 5(3) | 4(80) |
| Pateron D, et al.62 | 118 | 36 | AFP, DCP, and ultrasound | 14 (12) | 5(36) |
| Bolondi L, et al.64 | 313 | 56 | AFP and ultrasound | 57(18) | 53 (87) |
| Velazquez RF, et al.28 | 463 | 39 | AFP and ultrasound | 38(8) | 18 (47) |
| Sangiovanni A, et al.71 | 417 | 148 | AFP and ultrasound | 112(27) | 27 (24) |
| Santagostino E, et al.72 | 66 | 72 | AFP and ultrasound | 8(12) | 2(25) |
| Henrion J, et al.73 | 94 | 34 | AFP and ultrasound | 6(6) | 5(83) |
| Zoli M, et al.74 | 164 | 28 | AFP and ultrasound | 34 (21) | 32 (94) |
| Tradati F, et al.75 | 40 | 48 | AFP and ultrasound | 6(15) | 2(33) |
| Kobayashi K, et al.67 | 95 | 50 | AFP, ultrasound, and CT | 8(8) | 6(75) |
| Sheu JC, et al.68 | 223 | 17 | AFP and ultrasound | 7(3) | 7(100) |
| Oka H, et al.69 | 140 | 41 | AFP and ultrasound | 39 (28) | 27 (82) |
| Van Thiel DH, et al.70 | 100 | 20 | AFP, ultrasound, and triple-phase CT | 14 (14) | 13 (93) |
| Imberti D, et al.76 | 228 | 44 | AFP and ultrasound | 38 (17) | 14 (37) |
| Colombo M, et al.77 | 417 | 33 | AFP and ultrasound | 26(6) | 9(35) |
| Cottone M, et al.78 | 147 | 65 | AFP and ultrasound | 30 (20) | 25 (83) |
| Oka H, et al.69 | 260 | 39 | AFP and ultrasound | 55 (21) | 50 (91) |
| Degos F, et al.79 | 416 | 68 | AFP and ultrasound | 60 (14) | 37 (62) |
| Bruno S, et al.80 | 163 | 68 | AFP and ultrasound | 22(13) | 16 (73) |
| Caturelli E, et al.81 | 1599 | 43 | AFP and ultrasound | 269 (17) | 253 (94) |
| Tong MJ, et al.65 | 173 | 35 | AFP and ultrasound | 31 (18) | 18 (58) |
| Iavarone M, et al.82 | 201 | 50 | AFP and ultrasound | 27(13) | 17 (63) |
CT=computed tomography; DCP=des-gamma-:carboxy prothrombin.