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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Surgery. 2010 Dec;148(6):1228–1236. doi: 10.1016/j.surg.2010.09.026

Figure 6. Withaferin A treatment significantly reduces xenograft MTC tumor calcitonin production in vivo.

Figure 6

DRO 81-1 xenograft nu/nu mice were treated with withaferin A (5.0 mg/Kg/day) or with vehicle. Twenty-one days after treatment, animals were sacrificed to collect tissue samples and blood. Mouse serum calcitonin levels were measured using The Calcitonin Immunoassay from ALPCO Diagnostics (Salem, NH) using manufacturer controls. Graph is average of 3 animal samples with standard deviation error bars. WA treated animals had a significantly lower calcitonin (79 pg/mL) compared to controls (149 pg/mL; p<0.05) indicating the drug’s effect on tumor biochemical functionality.