Table 3. | Commonly used drugs in the treatment of hypercalciuric calcium nephrolithiasis.

Drug	Recommended dosage(s)	Comments
Hydrochlorothiazide	50 mg/day 25mg twice/day	A single dosage is preferred since the twice a day dosage may cause frequent nocturia and consequent patient discomfort.
Chlorthalidone	25 mg/day 50 mg/day	Both dosages lower urinary calcium by the same degree. Because of its long action, this treatment may cause hypokalemia and hypocitraturia.
Indapamide	1.2 mg/day 2.5 mg/day	This treatment may have fewer side effects that hydrochlorothiazide, including the rare occurrence of hypokalemia and hypotension.
Amiloride	5 mg/day	This treatment is a potassium sparing diuretic that lowers urinary calcium, but to a lesser degree than hydrochlorothiazide.
Amiloride/Hydrochlorothiazide	5 mg/50 mg/day	Maintains the hypocalciuric effect of thiazide, whereas averting the development of severe hypokalemia.
Trichlormethiazide	2 mg/day 4 mg/day	This drug is not marketed in the United States.