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Receptor and transporter selectivity for compounds 1a, 1b, and 1d.
| Compound | Ki, nM (±SEM)
|
||||
|---|---|---|---|---|---|
| 5-HT2Aa | 5-HT2Cb | D2c | SERTd | NETe | |
| 1af | 20 | 43 (5) | >10,000 | >10,000 | >10,000 |
| 1b | 1.3 | 3.3 (0.4) | >10,000 | 1,200 (160) | 4490 (1080) |
| 1d | 7.0 | 62 (6) | 6,280 (820) | 490 (9) | 845 (270) |
Radioligands:
[3H]ketanserin,
[3H]mesulergine,
[3H]spiperone,
[3H]paroxitine,
[3H]nisoxitine.
Data from ref. 6.
