Figure 5.

Ca²⁺-evoked exocytosis in IHCs from P2–P3 Syt2^−/− mice. A, Examples of Ca²⁺-evoked exocytosis in P2–P3 Syt2^+/+ and Syt2^−/− IHCs. Cells were stimulated by a 100 ms voltage step to −10 mV from a holding potential of −90 mV. B, Bar graph of average and individual I_Ca peak amplitudes and their corresponding ΔC_m values for Syt2^+/+ (n = 17) and Syt2^−/− (n = 10) IHCs. C, Kinetics of Ca²⁺-dependent exocytosis. Only cells with large ΔC_m responses were included for the analysis in this graph. D, Average cumulative ΔC_m responses from P2–P3 Syt2^+/+ and Syt2^−/− IHCs elicited using 50 ms repetitive voltage steps to −10 mV (interstep intervals of 100 ms).