Table 2.
Crude and adjusted association between EONI, clinical and histological chorioamnionitis and gestational age at delivery, antibiotics at admission, management of delivery, and routinely used infectious markers.
| Early Onset Neonatal Infection | Clinical Chorioamnionitis | Histological Chorioamnionitis | ||||
|---|---|---|---|---|---|---|
| Binary Variables |
OR [95% CI] |
Adjusted OR [95% CI]a |
OR [95% CI] |
Adjusted OR [95% CI]a |
OR [95% CI] |
Adjusted OR [95% CI]a |
| Gestational Age | ||||||
| < 37 | 0.8 [0.2, 3.6] | - | 0.3 [0.0, 2.2] | - | 1.1 [0.4, 3.1] | - |
| ≥ 37 | 1 | 1 | 1 | |||
| Antibiotic at admission | ||||||
| Yes | 0.7 [0.3, 2.1] | - | 0.5 [0.2, 1.5] | - | 0.6 [0.2, 1.3] | - |
| No | 1 | 1 | 1 | |||
| Management of delivery | ||||||
| Expectant | 0.4 [0.1, 1.6] | - | 0.6 [0.2, 1.8] | - | 1.6 [0.8, 3.5] | - |
| Active | 1 | 1 | 1 | |||
| Abnormal bacterial colonisation, genital tract | ||||||
| Yes | 2.7 [1.0, 7.2] | 2.2 [0.7, 6.6] | 1.8 [0.7, 4.6] | - | 1.2 [0.5, 2.7] | - |
| No | 1 | 1 | 1 | 1 | ||
| Continuous variablesb |
Coefficient [95% CI] |
Adjusted Coefficient [95% CI]a |
Coefficient [95% CI] |
Adjusted Coefficient [95% CI]a |
Coefficient [95% CI] |
Adjusted Coefficient [95% CI]a |
| CRP(mg/l) | 0.064 [0.035, 0.093] |
0.055 [0.024, 0.086] |
0.039 [0.016, 0.062] |
0.039 [0.016, 0.062] |
0.051 [0.022, 0.080] |
0.051 [0.022, 0.080] |
| WBC (giga/l) | 0.015 [0.007, 0.023] |
0.013 [0.003, 0.022]c |
0.0001 [-0.0001, 0.0002] |
- | 0.0001 [0.00003, 0.0002] |
- |
a Adjusted OR and coefficients for non-significant variables taken from the model just before their elimination after stepwise reduction; those for
significant variables come from the final model
b Coefficients for CRP and WBC were calculated from the logistic regression equation.
c The FP1 transformation used for WBC because of its non-linear association with EONI was: [(WBC/10000)7.6354-1.660493995].