Figure 10.
Test of the hypothesis of independent GABAC-mediated and propofol-enhanced GABAA-mediated contributions to the overall GABA-elicited response. (A, B) Comparison of the response to (10 μM GABA + propofol) (green) with rtest, a computationally derived response that represents the summed, hypothetically independent contributions of GABAA- and GABAC-mediated responses (purple). Results obtained with propofol concentrations of 150 μM (A) and 500 μM (B). (A, B) Keys identify the responses leading to the determination of rtest (equations 2a, 2b). Histograms at the right in each panel: ratios of peak amplitudes (equations 3a, 3b) that represent the test of independence at 150 and 500 μM propofol, respectively.